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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1lotATPActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1lotATPActin, alpha skeletal muscle/1.000
4pkhADPActin, alpha skeletal muscle/0.584
4k42ADPActin, alpha skeletal muscle/0.574
1kxpATPActin, alpha skeletal muscle/0.565
3mn6ATPActin-5C/0.548
3m6gATPActin, alpha skeletal muscle/0.547
4pl8ATPActin, alpha skeletal muscle/0.540
1h1vATPActin, alpha skeletal muscle/0.537
3mn9ATPActin-5C/0.529
4pkgATPActin, alpha skeletal muscle/0.529
4jhdANPActin-5C/0.527
3ffkATPActin, alpha skeletal muscle/0.526
1c0fATPMajor actin/0.522
5ce3ATPActin/0.517
3tu5ATPActin, alpha skeletal muscle/0.513
1ijjATPActin, alpha skeletal muscle/0.497
2q36ATPActin, alpha skeletal muscle/0.492
4pkiATPActin, alpha skeletal muscle/0.492
1nmdATPMajor actin/0.486
4ci6ATPActin/0.486
3m1fATPActin, alpha skeletal muscle/0.483
3u9dATPActin, alpha skeletal muscle/0.478
1rgiATPActin, alpha skeletal muscle/0.476
2v51ATPActin, alpha skeletal muscle/0.475
4m63ATPActin-5C/0.474
1nm1ATPMajor actin/0.473
3w3dATPActin, gamma-enteric smooth muscle/0.467
2q97ATPActin, alpha skeletal muscle/0.466
3chwATPMajor actin/0.462
1mduATPActin, alpha skeletal muscle/0.461
1nlvATPMajor actin/0.446
4rwtANPActin-5C/0.443