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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1kxpATPActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1kxpATPActin, alpha skeletal muscle/1.000
1lotATPActin, alpha skeletal muscle/0.613
4pkhADPActin, alpha skeletal muscle/0.556
1rgiATPActin, alpha skeletal muscle/0.550
4pl8ATPActin, alpha skeletal muscle/0.541
3m6gATPActin, alpha skeletal muscle/0.530
3mn6ATPActin-5C/0.529
4jhdANPActin-5C/0.528
4k42ADPActin, alpha skeletal muscle/0.528
3mn9ATPActin-5C/0.527
1c0fATPMajor actin/0.524
4pkgATPActin, alpha skeletal muscle/0.518
5ce3ATPActin/0.516
1nmdATPMajor actin/0.514
2q36ATPActin, alpha skeletal muscle/0.513
4pkiATPActin, alpha skeletal muscle/0.510
3ffkATPActin, alpha skeletal muscle/0.509
3tu5ATPActin, alpha skeletal muscle/0.508
1nm1ATPMajor actin/0.506
3m1fATPActin, alpha skeletal muscle/0.501
1ijjATPActin, alpha skeletal muscle/0.496
2v51ATPActin, alpha skeletal muscle/0.496
1mduATPActin, alpha skeletal muscle/0.494
1h1vATPActin, alpha skeletal muscle/0.483
3u9dATPActin, alpha skeletal muscle/0.478
1atnATPActin, alpha skeletal muscle/0.477
2a41ATPActin, alpha skeletal muscle/0.475
4m63ATPActin-5C/0.473
3u4lATPActin, cytoplasmic 1/0.469
3w3dATPActin, gamma-enteric smooth muscle/0.469
3a5oATPMajor actin/0.446
4rwtANPActin-5C/0.445
3chwATPMajor actin/0.444