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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1klkPMDDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1m7aMQUDihydrofolate reductase1.5.1.30.548
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.536
3k47D09Dihydrofolate reductase1.5.1.30.523
3jwm5WBDihydrofolate reductase/0.513
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.504
1dg8NDPDihydrofolate reductase1.5.1.30.493
3qlsNDPDihydrofolate reductase1.5.1.30.485
3r336MEDihydrofolate reductase1.5.1.30.478
2drcMTXDihydrofolate reductase1.5.1.30.461
4fgg0U5Dihydrofolate reductase1.5.1.30.459
3tqaNDPDihydrofolate reductase/0.451
1ysx4EBSerum albumin/0.446
4ixfIXFDihydrofolate reductase1.5.1.30.444
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
4zasTYDCalS13/0.441
3koo24DBifunctional epoxide hydrolase 23.3.2.100.440