sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 1.000 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.472 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.469 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.468 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.464 | |
| 3px3 | T3Q | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | 2.1.1.235 | 0.459 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.452 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.452 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.452 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.451 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.451 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.451 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.449 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.447 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.447 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.444 | |
| 2vou | FAD | 2,6-dihydroxypyridine 3-monooxygenase | 1.14.13.10 | 0.444 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.444 | |
| 1h74 | AGS | Homoserine kinase | 2.7.1.39 | 0.443 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.443 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.441 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.441 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.441 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.441 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.440 |