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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1gxfFADTrypanothione reductase1.8.1.12

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1gxfFADTrypanothione reductase1.8.1.121.000
1bzlFADTrypanothione reductase1.8.1.120.589
2jk6FADTrypanothione reductase/0.582
4dnaFADProbable glutathione reductase/0.581
1fecFADTrypanothione reductase1.8.1.120.578
2hqmFADGlutathione reductase1.8.1.70.567
2wbaFADTrypanothione reductase1.8.1.120.562
1tytFADTrypanothione reductase1.8.1.120.559
1grhFADGlutathione reductase, mitochondrial1.8.1.70.541
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.540
4j56FADThioredoxin reductase 21.8.1.90.523
1febFADTrypanothione reductase1.8.1.120.519
4la1FADThioredoxin glutathione reductase/0.498
3grsFADGlutathione reductase, mitochondrial1.8.1.70.478
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.471
4fx9FADCoenzyme A disulfide reductase1.8.1.140.460
3ntaFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.451
4j57FADThioredoxin reductase 21.8.1.90.448
2tprFADTrypanothione reductase1.8.1.120.445
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.442
1dncFADGlutathione reductase, mitochondrial1.8.1.70.441
3ntdFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.441