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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1gotGDPGuanine nucleotide-binding protein G(t) subunit alpha-1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1gotGDPGuanine nucleotide-binding protein G(t) subunit alpha-1/1.000
1gilGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.487
1giaGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.480
3h86AP5Adenylate kinase/0.471
1y3aGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.470
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.467
3c16GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.460
3hyoADPPyridoxal kinase/0.459
4fidGDPG protein alpha subunit, putative/0.455
3c15GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.453
1qf4RPDAdenylosuccinate synthetase/0.452
1aztGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.449
5jscFADPutative acyl-CoA dehydrogenase/0.447
3b6zCO7Enoyl reductase LovC10.445
1h6dNDPGlucose--fructose oxidoreductase1.1.99.280.444
3b70NAPEnoyl reductase LovC10.444
3intGDUUDP-galactopyranose mutase5.4.99.90.444
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.443
1culGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.442
1cg3IMOAdenylosuccinate synthetase/0.440
3l9hEMQKinesin-like protein KIF11/0.440