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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1getFADGlutathione reductase1.8.1.7

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1getFADGlutathione reductase1.8.1.71.000
1geuFADGlutathione reductase1.8.1.70.732
1gerFADGlutathione reductase1.8.1.70.710
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.519
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.517
2rabFADGlutathione amide reductase/0.497
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.478
1grbFADGlutathione reductase, mitochondrial1.8.1.70.472
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.472
3djgFADGlutathione reductase, mitochondrial1.8.1.70.466
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.465
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.464
2r9zFADGlutathione amide reductase/0.463
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.462
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.453
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.452
2eq7FADDihydrolipoyl dehydrogenase/0.451
3grsFADGlutathione reductase, mitochondrial1.8.1.70.448
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.447
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.447
3ic9FADPutative dihydrolipoamide dehydrogenase/0.447
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.446
3cgdFADCoenzyme A disulfide reductase/0.446
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.446
1feaFADTrypanothione reductase1.8.1.120.445
2eq8FADDihydrolipoyl dehydrogenase/0.444
1grhFADGlutathione reductase, mitochondrial1.8.1.70.443
1febFADTrypanothione reductase1.8.1.120.442
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.442