sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1f5n | GNP | Guanylate-binding protein 1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1f5n | GNP | Guanylate-binding protein 1 | / | 1.000 | |
| 2bc9 | GNP | Guanylate-binding protein 1 | / | 0.478 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.471 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.470 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.469 | |
| 3q5d | GDP | Atlastin-1 | 3.6.5 | 0.469 | |
| 3e8x | NAP | BH1520 protein | / | 0.466 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.465 | |
| 4y9q | C2E | Uncharacterized protein | / | 0.464 | |
| 1qrr | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.463 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.463 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.463 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.462 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.459 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.457 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.455 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.454 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.450 | |
| 1gle | ADP | Glycerol kinase | / | 0.449 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.449 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.449 | |
| 3zux | TCH | Transporter | / | 0.449 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.447 | |
| 3lpf | Z77 | Beta-glucuronidase | 3.2.1.31 | 0.447 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.446 | |
| 1xnj | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 2.7.1.25 | 0.446 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.446 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.445 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.445 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.444 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.444 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.443 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.443 | |
| 3a4l | ANP | L-seryl-tRNA(Sec) kinase | 2.7.1.164 | 0.443 | |
| 3t58 | FAD | Sulfhydryl oxidase 1 | 1.8.3.2 | 0.443 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4i0b | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.443 | |
| 4idn | GNP | Atlastin-1 | 3.6.5 | 0.443 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.442 | |
| 1svw | GTP | Probable GTP-binding protein EngB | / | 0.442 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.442 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.442 | |
| 3lt2 | FT3 | Enoyl-ACP reductase | / | 0.442 | |
| 1i6x | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.441 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.441 | |
| 3c3n | FMN | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.441 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.441 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.441 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.440 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.440 | |
| 2d4v | NAD | Isocitrate dehydrogenase [NADP] | / | 0.440 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.440 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.440 |