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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1errRALEstrogen receptor

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1errRALEstrogen receptor/1.000
1yinCM3Estrogen receptor/0.583
1xqcAEJEstrogen receptor/0.557
1sj0E4DEstrogen receptor/0.544
1xp6AIUEstrogen receptor/0.520
2jf9OHTEstrogen receptor/0.516
1uomPTIEstrogen receptor/0.510
1qknRALEstrogen receptor beta/0.500
1ndeMONEstrogen receptor beta/0.489
2jfaRALEstrogen receptor/0.484
2gpvOHTEstrogen-related receptor gamma/0.473
2pogWSTEstrogen receptor/0.473
1zgaHMKIsoflavone 4'-O-methyltransferase/0.470
2bj4OHTEstrogen receptor/0.464
4ubsDIFPentalenic acid synthase1.14.15.110.457
2qe4JJ3Estrogen receptor/0.456
2fszOHTEstrogen receptor beta/0.455
4cd2FOLDihydrofolate reductase1.5.1.30.454
4iv41GSEstrogen receptor/0.454
2p7zOHTEstrogen-related receptor gamma/0.452
3bfa9ODOdorant binding protein ASP1/0.451
4ivw1GJEstrogen receptor/0.450
2z7gEH9Adenosine deaminase3.5.4.40.448
3bfb9ODPheromone-binding protein ASP1/0.448
3qlrNDPDihydrofolate reductase1.5.1.30.447
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.446
3zoiM2WIsopenicillin N synthase1.21.3.10.446
4z9g1Q5Corticotropin-releasing factor receptor 1/0.444
1ai9NDPDihydrofolate reductase1.5.1.30.441
2acwUPGGlycosyltransferase/0.441
1eioGCHGastrotropin/0.440