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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1c0fATPMajor actin

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1c0fATPMajor actin/1.000
4k42ADPActin, alpha skeletal muscle/0.614
4pkhADPActin, alpha skeletal muscle/0.581
3ffkATPActin, alpha skeletal muscle/0.572
3mn6ATPActin-5C/0.561
1lotATPActin, alpha skeletal muscle/0.560
3m6gATPActin, alpha skeletal muscle/0.558
4m63ATPActin-5C/0.558
1h1vATPActin, alpha skeletal muscle/0.557
3mn9ATPActin-5C/0.556
4jhdANPActin-5C/0.550
3tu5ATPActin, alpha skeletal muscle/0.547
5ce3ATPActin/0.545
2q36ATPActin, alpha skeletal muscle/0.543
4pkgATPActin, alpha skeletal muscle/0.540
2v51ATPActin, alpha skeletal muscle/0.539
4pl8ATPActin, alpha skeletal muscle/0.539
3chwATPMajor actin/0.528
3u9dATPActin, alpha skeletal muscle/0.525
1ijjATPActin, alpha skeletal muscle/0.524
4ci6ATPActin/0.524
4rwtANPActin-5C/0.509
1nmdATPMajor actin/0.508
3a5mATPMajor actin/0.506
3m1fATPActin, alpha skeletal muscle/0.505
4pkiATPActin, alpha skeletal muscle/0.504
1kxpATPActin, alpha skeletal muscle/0.499
1mduATPActin, alpha skeletal muscle/0.497
1nm1ATPMajor actin/0.492
3w3dATPActin, gamma-enteric smooth muscle/0.490
1nlvATPMajor actin/0.463
2q97ATPActin, alpha skeletal muscle/0.458
3ekuATPActin-5C/0.451
3a5oATPMajor actin/0.442
3u4lATPActin, cytoplasmic 1/0.440