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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5dnrATPAurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5dnrATPAurora kinase A2.7.11.11.000
4deeADPAurora kinase A2.7.11.10.573
5dosATPAurora kinase A2.7.11.10.551
5dn3ATPAurora kinase A2.7.11.10.547
4jbpYPHAurora kinase A2.7.11.10.495
1ig1ANPDeath-associated protein kinase 12.7.11.10.475
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.470
4jboWPHAurora kinase A2.7.11.10.469
4c3pACPAurora kinase A2.7.11.10.465
4qnyANPMitogen activated protein kinase, putative/0.465
3c4wATPRhodopsin kinase/0.463
3c4zADPRhodopsin kinase/0.462
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.460
2w4jADPDeath-associated protein kinase 12.7.11.10.457
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.454
4j95ACPFibroblast growth factor receptor 2/0.453
5dt3ATPAurora kinase A2.7.11.10.446
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.445
3gu7ADPDeath-associated protein kinase 12.7.11.10.443