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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5by6UMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5by6UMPThymidylate synthase/1.000
3qj7UMPThymidylate synthase ThyA/0.608
4irrUMPThymidylate synthase/0.593
4eb4UMPThymidylate synthase2.1.1.450.568
4dq1UMPThymidylate synthase/0.557
4einNOHThymidylate synthase2.1.1.450.541
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.538
4e5oUMPThymidylate synthase2.1.1.450.528
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.516
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.509
1bidUMPThymidylate synthase/0.503
1ci7UMPThymidylate synthase2.1.1.450.503
2tsrUMPThymidylate synthase2.1.1.450.498
1aobDDUThymidylate synthase/0.496
4psgNOHThymidylate synthase/0.496
4xsdUMPThymidylate synthase2.1.1.450.496
4h0uUMPThymidylate synthase/0.485
2g8aUMPThymidylate synthase/0.483
2g86UMPThymidylate synthase/0.480
4iskUMPThymidylate synthase/0.479
1bduDURThymidylate synthase/0.476
1dduDDUThymidylate synthase/0.476
2tdmUMPThymidylate synthase/0.476
2vetUMPThymidylate synthase/0.472
1jmgUMPThymidylate synthase/0.471
1njbUMPThymidylate synthase/0.470
1njdUMPThymidylate synthase/0.469
1tsvUMPThymidylate synthase/0.469
1njeDCMThymidylate synthase/0.466
1tsyUMPThymidylate synthase/0.463
1jmiUMPThymidylate synthase/0.462
3hb8UMPThymidylate synthase2.1.1.450.461
4foxUMPThymidylate synthase ThyA/0.459
1jmfUMPThymidylate synthase/0.455
1tsxUMPThymidylate synthase/0.454
1vzbUMPThymidylate synthase/0.446
2g89UMPThymidylate synthase/0.446
1njaDCMThymidylate synthase/0.443