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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/1.000
4nbwNADShort-chain dehydrogenase/reductase SDR/0.519
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.517
1g6kNADGlucose 1-dehydrogenase1.1.1.470.512
4k6fNAPPutative Acetoacetyl-CoA reductase/0.507
4dc0NDPPutative ketoacyl reductase1.3.10.505
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.500
3lqfNADGalactitol dehydrogenase/0.493
1b2lNDCAlcohol dehydrogenase1.1.1.10.491
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.472
1dirNADDihydropteridine reductase1.5.1.340.465
4ambDUDPutative glycosyl transferase/0.462
3orfNADDihydropteridine reductase1.5.1.340.461
4dbzNDPPutative ketoacyl reductase1.3.10.461
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.460
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
5jlaNADPutative short-chain dehydrogenase/reductase/0.458
1w6hTITPlasmepsin-23.4.23.390.456
3ai3NDPNADPH-sorbose reductase/0.456
2y4gTIRTamL/0.455
1xe55FEPlasmepsin-23.4.23.390.452
2c29NAPDihydroflavonol 4-reductase/0.452
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.452
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.450
4zowCLMMultidrug transporter MdfA/0.449
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.447
1dhrNADDihydropteridine reductase1.5.1.340.445
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.443
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.443
3ai2NDPNADPH-sorbose reductase/0.443
4q71FADBifunctional protein PutA/0.443
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
2g1n1IGRenin3.4.23.150.442
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.442
4idgNADPutative UDP-glucose 4-epimerase/0.442
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.442
4bfwZVWPantothenate kinase2.7.1.330.440
4bfxZVXPantothenate kinase2.7.1.330.440