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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4zgsNADPutative D-lactate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4zgsNADPutative D-lactate dehydrogenase/1.000
1j49NADD-lactate dehydrogenase1.1.1.280.495
2p9gNAID-3-phosphoglycerate dehydrogenase1.1.1.950.471
2pa3NAID-3-phosphoglycerate dehydrogenase1.1.1.950.465
1ybaNADD-3-phosphoglycerate dehydrogenase1.1.1.950.459
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.459
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.456
4cukNAID-lactate dehydrogenase/0.453
2p9eNAID-3-phosphoglycerate dehydrogenase1.1.1.950.441