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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ys22BAUncharacterized protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ys22BAUncharacterized protein/1.000
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.489
4k6fNAPPutative Acetoacetyl-CoA reductase/0.481
2lfoGCHFatty acid-binding protein, liver/0.476
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.470
4dc0NDPPutative ketoacyl reductase1.3.10.470
2hw2RFPRifampin ADP-ribosyl transferase/0.469
4q71FADBifunctional protein PutA/0.466
1bim0QBRenin3.4.23.150.462
2iko7IGRenin3.4.23.150.462
2iyaZIOOleandomycin glycosyltransferase/0.462
2xgs44PUncharacterized protein/0.460
3lqfNADGalactitol dehydrogenase/0.459
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.457
1x8lOXRRetinol dehydratase/0.454
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.454
1f8fNADBenzyl alcohol dehydrogenase/0.453
1kceCB3Thymidylate synthase/0.452
2fznFADBifunctional protein PutA1.5.5.20.452
4nbwNADShort-chain dehydrogenase/reductase SDR/0.452
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.451
3p3zP3ZPutative cytochrome P450/0.451
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.450
4bb3KKAIsopenicillin N synthase1.21.3.10.450
4l4eCAMCamphor 5-monooxygenase1.14.15.10.450
4l4fCAMCamphor 5-monooxygenase1.14.15.10.450
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.449
1mczTDPBenzoylformate decarboxylase4.1.1.70.448
3oqfS51Renin3.4.23.150.448
1o76CAMCamphor 5-monooxygenase1.14.15.10.447
1vrwNAIEnoyl-ACP reductase/0.447
2ikuLIYRenin3.4.23.150.447
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
2rqfJH3Hemolymph juvenile hormone binding protein/0.446
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.446
1fmlRTLRetinol dehydratase/0.445
1mczRMNBenzoylformate decarboxylase4.1.1.70.445
3fwfCAMCamphor 5-monooxygenase1.14.15.10.445
1tl7FOKAdenylate cyclase type 2/0.444
1tl7FOKAdenylate cyclase type 5/0.444
1u3dFADCryptochrome-1/0.444
2xviFADPutative flavin-containing monooxygenase/0.444
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
4djaFAD(6-4) photolyase/0.444
4uymVOR14-alpha sterol demethylase Cyp51B/0.444
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
2c29NAPDihydroflavonol 4-reductase/0.443
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.443
2xgoZKDUncharacterized protein/0.443
4o1mNADEnoyl-acyl carrier reductase/0.443
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
2v58LZJBiotin carboxylase6.3.4.140.441
4dbzNDPPutative ketoacyl reductase1.3.10.441
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.440
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440