sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ybr | NAP | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4ybr | NAP | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 1.000 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.472 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.471 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.470 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.464 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.464 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.461 | |
| 3zcs | CAW | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.460 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.457 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.455 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 3r9i | ADP | Septum site-determining protein MinD | / | 0.448 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.448 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.447 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.447 | |
| 3lst | SAH | CalO1 | / | 0.447 | |
| 4kto | FAD | Putative isovaleryl-CoA dehydrogenase protein | / | 0.447 | |
| 4y9u | NAP | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.446 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.446 | |
| 2cv1 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.445 | |
| 2dxi | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.445 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.444 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.444 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.443 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.443 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.442 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.442 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.442 | |
| 4jic | FMN | GTN Reductase | / | 0.442 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.441 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.440 |