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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4xznNAPAldo-keto reductase family 1 member B101.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4xznNAPAldo-keto reductase family 1 member B101.1.11.000
4xzmNAPAldo-keto reductase family 1 member B101.1.10.619
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.551
2j8tNAPAldose reductase1.1.1.210.546
2vdgNDPAldose reductase1.1.1.210.541
2iq0NAPAldose reductase1.1.1.210.540
1x96NAPAldose reductase1.1.1.210.533
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.525
1ah4NAPAldose reductase1.1.1.210.522
4g5dNDPProstaglandin F synthase1.1.1.1880.522
2pevNDPAldose reductase1.1.1.210.515
3h7rNAPAldo-keto reductase family 4 member C8/0.513
2acqNAPAldose reductase1.1.1.210.511
1x98NAPAldose reductase1.1.1.210.508
1az2NAPAldose reductase1.1.1.210.505
3v36NAPAldose reductase1.1.1.210.495
2pf8NDPAldose reductase1.1.1.210.494
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.490
4pmjNAPPutative oxidoreductase/0.488
3q65NAPAldose reductase1.1.1.210.486
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.484
1z8aNAPAldose reductase1.1.1.210.481
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.480
2pfhNDPAldose reductase1.1.1.210.480
3qkzNAPAldose reductase-related protein 11.1.1.210.479
1adsNAPAldose reductase1.1.1.210.476
2acsNAPAldose reductase1.1.1.210.476
1ef3NAPAldose reductase1.1.1.210.474
5c7hNDPPutative oxidoreductase/0.470
1c9wNAPAldose reductase-related protein 2/0.469
3q67NAPAldose reductase1.1.1.210.469
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.466
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.465
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.460
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.459
2acuNAPAldose reductase1.1.1.210.457
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.453
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.452
1vp5NAPOxidoreductase, aldo/keto reductase family/0.443