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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4xp4COCSodium-dependent dopamine transporter

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4xp4COCSodium-dependent dopamine transporter/1.000
4xp1LDPSodium-dependent dopamine transporter/0.534
4m4821BSodium-dependent dopamine transporter/0.520
4mmd29ENa(+):neurotransmitter symporter (Snf family)/0.515
4mmc29JNa(+):neurotransmitter symporter (Snf family)/0.509
4mm9FVXNa(+):neurotransmitter symporter (Snf family)/0.475
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.461
4mmf29QNa(+):neurotransmitter symporter (Snf family)/0.461
4mm48PRNa(+):neurotransmitter symporter (Snf family)/0.447
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.445
4mme29QNa(+):neurotransmitter symporter (Snf family)/0.444