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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4xbfFADLysine-specific histone demethylase 1A1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4xbfFADLysine-specific histone demethylase 1A11.000
2dw4FADLysine-specific histone demethylase 1A10.628
2uxxFAJLysine-specific histone demethylase 1A10.616
2hkoFADLysine-specific histone demethylase 1A10.609
4fwjFADLysine-specific histone demethylase 1B10.543
2h94FADLysine-specific histone demethylase 1A10.525
3bi5FADPolyamine oxidase FMS1/0.520
4echFADPolyamine oxidase FMS1/0.520
3bi2FADPolyamine oxidase FMS1/0.505
4gutFADLysine-specific histone demethylase 1B10.494
3cndFADPolyamine oxidase FMS1/0.493
4gdpFADPolyamine oxidase FMS1/0.491
4fweFADLysine-specific histone demethylase 1B10.486
3cn8FADPolyamine oxidase FMS1/0.475
3k7tFAD6-hydroxy-L-nicotine oxidase/0.475
4guuFA9Lysine-specific histone demethylase 1B10.468
2yg4FADPutrescine oxidase/0.465
4bfvZVVPantothenate kinase2.7.1.330.458
2g8yNADHydroxycarboxylate dehydrogenase B/0.457
3k7mFAD6-hydroxy-L-nicotine oxidase/0.457
4bfxZVXPantothenate kinase2.7.1.330.454
3cntFADPolyamine oxidase FMS1/0.452
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.448
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.447
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4bftZVTPantothenate kinase2.7.1.330.446
3ig6438Urokinase-type plasminogen activator3.4.21.730.444
1sezFADProtoporphyrinogen oxidase, mitochondrial1.3.3.40.443
4q72FADBifunctional protein PutA/0.441
1rsgFADPolyamine oxidase FMS1/0.440
2ok7FADFerredoxin--NADP reductase, apicoplast/0.440
2vvlFADMonoamine oxidase N1.4.3.40.440
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.440