sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4utk | FNR | Xenobiotic reductase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4utk | FNR | Xenobiotic reductase | / | 1.000 | |
| 4utl | FNR | Xenobiotic reductase | / | 0.692 | |
| 3n19 | FNR | Xenobiotic reductase | / | 0.646 | |
| 3l5l | FMN | Xenobiotic reductase | / | 0.580 | |
| 3hgr | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.568 | |
| 3hgs | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.558 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.552 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.550 | |
| 2q3o | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.541 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.539 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.538 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.537 | |
| 4b5n | FMN | NAD(P)H:flavin oxidoreductase Sye4 | / | 0.533 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.531 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.530 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.529 | |
| 1z44 | FMN | NADPH dehydrogenase | / | 0.528 | |
| 4a3u | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.525 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.518 | |
| 4uth | FMN | Xenobiotic reductase | / | 0.518 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.517 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.512 | |
| 4tmb | FMN | Old yellow enzyme | / | 0.512 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.510 | |
| 3l67 | FMN | Xenobiotic reductase | / | 0.508 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.506 | |
| 4rnv | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.489 | |
| 2gou | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.488 | |
| 3n14 | FMN | Xenobiotic reductase | / | 0.488 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.488 | |
| 1z41 | FMN | NADPH dehydrogenase | / | 0.487 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.485 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.484 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.483 | |
| 2j6x | FMN | Lactate oxidase | / | 0.480 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.479 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.475 | |
| 2eix | FAD | NADH-cytochrome b5 reductase | / | 0.474 | |
| 2ga9 | AGS | Poly(A) polymerase catalytic subunit | 2.7.7.19 | 0.471 | |
| 4jic | FMN | GTN Reductase | / | 0.470 | |
| 2e77 | FMN | Lactate oxidase | / | 0.469 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 1oyc | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.467 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.466 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.466 | |
| 3kru | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.465 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.464 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 4awt | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.463 | |
| 2h8x | FMN | XenA | / | 0.461 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1bwk | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.460 | |
| 1oya | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.460 | |
| 3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.459 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.459 | |
| 5ebu | FMN | Lactate oxidase | / | 0.459 | |
| 3gr8 | FMN | NADPH dehydrogenase | / | 0.458 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 4rnx | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.458 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4h6k | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.454 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.454 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.452 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.452 | |
| 3tjl | FMN | NADPH dehydrogenase | / | 0.451 | |
| 5cpm | FNR | NADH:flavin oxidoreductase | / | 0.451 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.449 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.449 | |
| 2gqa | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.448 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.448 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.447 | |
| 3bac | 3B9 | DNA ligase | / | 0.447 | |
| 4bf9 | FMN | tRNA-dihydrouridine(16) synthase | / | 0.447 | |
| 1ryd | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.446 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.446 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.446 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.446 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.445 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.444 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.444 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.444 | |
| 4h0v | NAD | Iota toxin component Ia | / | 0.443 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.442 | |
| 4e2d | FMN | Dehydrogenase | / | 0.441 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.440 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.440 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 2nli | FMN | Lactate oxidase | / | 0.440 | |
| 2vet | UMP | Thymidylate synthase | / | 0.440 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.440 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.440 |