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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4uhrNGIAdenosine receptor A2a

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4uhrNGIAdenosine receptor A2a/1.000
4ug2NGIAdenosine receptor A2a/0.568
5k2aZMAAdenosine receptor A2a/0.558
5k2dZMAAdenosine receptor A2a/0.547
5uviZMAAdenosine receptor A2a/0.546
5k2bZMAAdenosine receptor A2a/0.544
5k2cZMAAdenosine receptor A2a/0.543
5jtbZMAAdenosine receptor A2a/0.543
5iu86DZAdenosine receptor A2a/0.538
5iua6DXAdenosine receptor A2a/0.537
2ydvNECAdenosine receptor A2a/0.523
2ydoADNAdenosine receptor A2a/0.516
5iubCLRAdenosine receptor A2a/0.512
4eiyZMAAdenosine receptor A2a/0.506
5iu4ZMAAdenosine receptor A2a/0.504
3emlZMAAdenosine receptor A2a/0.497
3pwhZMAAdenosine receptor A2a/0.494
5g53NECAdenosine receptor A2a/0.491
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.483
1osvCHCBile acid receptor/0.482
4iaq2GM5-hydroxytryptamine receptor 1B/0.475
3qakUKAAdenosine receptor A2a/0.463
3jynNDPQuinone oxidoreductase/0.461
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.461
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.455
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.455
4j6bPLOCytochrome P450 monooxygenase/0.455
4nc3ERM5-hydroxytryptamine receptor 2B/0.454
4qbjNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.449
1lriCLRBeta-elicitin cryptogein/0.448
3abaFLICytochrome P450/0.448
4d7eFADPutative lysine-N-oxygenase/0.448
3reyXACAdenosine receptor A2a/0.448
2aibERGBeta-elicitin cinnamomin/0.447
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.446
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.446
4j6cSTRCytochrome P450 monooxygenase/0.446
3p6nDSOCamphor 5-monooxygenase1.14.15.10.445
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.444
3livE16Protease/0.444
3ol5SAWCamphor 5-monooxygenase1.14.15.10.444
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.442
3bhlTHGThymidylate synthase/0.442
3t8xT8XT-cell surface glycoprotein CD1b/0.442
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3icsCOACoenzyme A disulfide reductase/0.441
3p6oETGCamphor 5-monooxygenase1.14.15.10.441
3vg9ZMAAdenosine receptor A2a/0.441
4knzCB3Thymidylate synthase/0.441
1nueGDPNucleoside diphosphate kinase B2.7.4.60.440
1zhwHC2Oxysterol-binding protein homolog 4/0.440
3p6mDSOCamphor 5-monooxygenase1.14.15.10.440
4isk1JYThymidylate synthase/0.440