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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4tl8AGSCircadian clock protein kinase KaiC2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4tl8AGSCircadian clock protein kinase KaiC2.7.11.11.000
4tleAGSCircadian clock protein kinase KaiC2.7.11.10.777
4tldAGSCircadian clock protein kinase KaiC2.7.11.10.586
4tl6ANPCircadian clock protein kinase KaiC2.7.11.10.584
4tl9AGSCircadian clock protein kinase KaiC2.7.11.10.584
4tl7ATPCircadian clock protein kinase KaiC2.7.11.10.573
4tlcAGSCircadian clock protein kinase KaiC2.7.11.10.571
3s1aATPCircadian clock protein kinase KaiC2.7.11.10.554
4o0mATPCircadian clock protein kinase KaiC2.7.11.10.549
3jzmATPCircadian clock protein kinase KaiC2.7.11.10.546
4tlbAGSCircadian clock protein kinase KaiC2.7.11.10.546
3dvlATPCircadian clock protein kinase KaiC2.7.11.10.539
1tf7ATPCircadian clock protein kinase KaiC2.7.11.10.534
1u9iATPCircadian clock protein kinase KaiC2.7.11.10.531
2gblATPCircadian clock protein kinase KaiC2.7.11.10.516
3k0fATPCircadian clock protein kinase KaiC2.7.11.10.507
2dr3ADPUPF0273 protein PH0284/0.478
4tlaADPCircadian clock protein kinase KaiC2.7.11.10.471