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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4rwtANPActin-5C

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4rwtANPActin-5C/1.000
4jhdANPActin-5C/0.534
4m63ATPActin-5C/0.506
3a5mATPMajor actin/0.501
1t44ATPActin, alpha skeletal muscle/0.484
3tu5ATPActin, alpha skeletal muscle/0.478
5ce3ATPActin/0.478
2v51ATPActin, alpha skeletal muscle/0.477
3m6gATPActin, alpha skeletal muscle/0.476
4pl8ATPActin, alpha skeletal muscle/0.475
4cbxATPActin-2/0.474
4pkhADPActin, alpha skeletal muscle/0.474
3u9dATPActin, alpha skeletal muscle/0.472
1h1vATPActin, alpha skeletal muscle/0.470
1c0fATPMajor actin/0.469
3mn6ATPActin-5C/0.467
3u4lATPActin, cytoplasmic 1/0.467
4k42ADPActin, alpha skeletal muscle/0.466
1s22ATPActin, alpha skeletal muscle/0.465
2q36ATPActin, alpha skeletal muscle/0.465
1lotATPActin, alpha skeletal muscle/0.461
2p9kATPActin-related protein 2/0.458
3mn9ATPActin-5C/0.456
3ffkATPActin, alpha skeletal muscle/0.454
1rgiATPActin, alpha skeletal muscle/0.453
4pkgATPActin, alpha skeletal muscle/0.452
1ijjATPActin, alpha skeletal muscle/0.447
4ci6ATPActin/0.444