sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4oae | CLM | Uncharacterized protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4oae | CLM | Uncharacterized protein | / | 1.000 | |
| 4oad | CLM | Uncharacterized protein | / | 0.652 | |
| 3pgp | ACO | Uncharacterized protein | / | 0.582 | |
| 4kub | COA | Uncharacterized protein | / | 0.516 | |
| 1s5k | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.469 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.468 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.467 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.467 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.464 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.463 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.462 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.462 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.458 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.458 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.456 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.456 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.455 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.455 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.454 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.453 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.453 | |
| 4jwp | ACO | GCN5-related N-acetyltransferase | / | 0.453 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.453 | |
| 3gob | HXX | DdmC | / | 0.452 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.452 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.452 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.452 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.451 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.450 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.449 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1s3z | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.449 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.448 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 1ol7 | ADP | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.446 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.445 | |
| 2vbq | BSJ | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.445 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.445 | |
| 3f8k | COA | Uncharacterized protein | / | 0.445 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.443 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1yre | COA | Uncharacterized protein | / | 0.443 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.443 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.443 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.443 | |
| 5ahs | COA | Acyl-CoA dehydrogenase | / | 0.443 | |
| 1m4i | COA | Aminoglycoside 2'-N-acetyltransferase | 2.3.1 | 0.442 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 5cts | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.442 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.441 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.441 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.441 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 1s60 | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.440 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.440 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.440 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.440 |