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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ntdFADThioredoxin reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ntdFADThioredoxin reductase/1.000
2ylzFADPhenylacetone monooxygenase1.14.13.920.492
5idwNAPShort-chain dehydrogenase/reductase SDR/0.460
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.457
3vqrFADPutative oxidoreductase/0.453
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.451
3k4cFADPyranose 2-oxidase/0.449
4tlxFDAKtzI/0.449
2ylsFADPhenylacetone monooxygenase1.14.13.920.447
3kybFADUDP-galactopyranose mutase5.4.99.90.447
3uklFADUDP-galactopyranose mutase/0.446
3nn6FB06-hydroxy-L-nicotine oxidase/0.445
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4opiFDAConserved Archaeal protein/0.445
1g6kNADGlucose 1-dehydrogenase1.1.1.470.444
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.444
2ylxFADPhenylacetone monooxygenase1.14.13.920.443
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.442
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.442
4u8iFDAUDP-galactopyranose mutase/0.442
3ctyFADProbable thioredoxin reductase/0.441
2ylrFADPhenylacetone monooxygenase1.14.13.920.440