sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 1.000 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.648 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.643 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.564 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.553 | |
| 5a1t | NAI | L-lactate dehydrogenase | / | 0.547 | |
| 4wlu | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.535 | |
| 1pzg | A3D | Lactate dehydrogenase | / | 0.533 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.532 | |
| 1sow | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.526 | |
| 1pzf | A3D | Lactate dehydrogenase | / | 0.513 | |
| 2hjr | APR | Malate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase | / | 0.512 | |
| 1t2d | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.511 | |
| 5mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.501 | |
| 4l4s | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.499 | |
| 1ie3 | NAD | Malate dehydrogenase | / | 0.492 | |
| 4wlv | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.486 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.477 | |
| 4wlo | NAI | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.473 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.472 | |
| 1hyh | NAD | L-2-hydroxyisocaproate dehydrogenase | / | 0.471 | |
| 4ajo | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.471 | |
| 4ajp | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.470 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.456 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.455 | |
| 4okn | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.455 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.453 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.452 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.452 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.452 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.449 | |
| 2vhv | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.446 | |
| 1nq5 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.444 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.442 | |
| 2gsd | NAD | Formate dehydrogenase | / | 0.442 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.442 |