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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4mk029XBeta-adrenergic receptor kinase 12.7.11.15

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4mk029XBeta-adrenergic receptor kinase 12.7.11.151.000
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.150.577
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.501
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.494
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
4fv6E57Mitogen-activated protein kinase 12.7.11.240.487
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.480
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
3i60E86Mitogen-activated protein kinase 12.7.11.240.473
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
5av2KMPDeath-associated protein kinase 12.7.11.10.467
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.463
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
4qnyANPMitogen activated protein kinase, putative/0.463
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4j95ACPFibroblast growth factor receptor 2/0.462
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.460
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.459
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.457
4j99ACPFibroblast growth factor receptor 2/0.457
5av3KMPDeath-associated protein kinase 12.7.11.10.457
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.454
3ncz3NCRho-associated protein kinase 12.7.11.10.453
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.453
3a8wATPProtein kinase C iota type2.7.11.130.451
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3lltANPProtein serine/threonine kinase-1/0.450
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.449
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2yaaATPDeath-associated protein kinase 2/0.448
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.448
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.447
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.446
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.446
2ojj82AMitogen-activated protein kinase 12.7.11.240.445
3gu7ADPDeath-associated protein kinase 12.7.11.10.443
3dfcANPDeath-associated protein kinase 12.7.11.10.442
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440