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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4lnbED5CaaX farnesyltransferase beta subunit Ram1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4lnbED5CaaX farnesyltransferase beta subunit Ram1/1.000
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.509
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.499
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.492
1s63778Protein farnesyltransferase subunit beta2.5.1.580.490
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.486
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.484
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.483
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.481
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.479
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.479
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.477
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.477
4lngJANCaaX farnesyltransferase beta subunit Ram1/0.465
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.458
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.453
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.450
4gtm7TMProtein farnesyltransferase subunit beta2.5.1.580.450