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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4l98LRGPeroxisome proliferator-activated receptor gamma

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4l98LRGPeroxisome proliferator-activated receptor gamma/1.000
1zeoC01Peroxisome proliferator-activated receptor gamma/0.509
1k74544Peroxisome proliferator-activated receptor gamma/0.489
1kkq471Peroxisome proliferator-activated receptor alpha/0.475
4fk8FADFerredoxin--NADP reductase/0.464
1knuYPAPeroxisome proliferator-activated receptor gamma/0.463
3gbk2PQPeroxisome proliferator-activated receptor gamma/0.463
4r21STRCytochrome P450 family 17 polypeptide 2/0.462
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.460
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.460
3qwbNDPProbable quinone oxidoreductase1.6.5.50.457
2uxoTACHTH-type transcriptional regulator TtgR/0.456
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.452
3vspEK8Peroxisome proliferator-activated receptor gamma/0.452
4q71FADBifunctional protein PutA/0.448
4q73FADBifunctional protein PutA/0.448
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
2ywlFADThioredoxin reductase related protein/0.444
4emaBRLPeroxisome proliferator-activated receptor gamma/0.444
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441