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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4knzCB3Thymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4knzCB3Thymidylate synthase/1.000
4gevCB3Thymidylate synthase/0.588
2ftoCB3Thymidylate synthase/0.582
3bhlTHGThymidylate synthase/0.574
3bgxMEFThymidylate synthase/0.559
4isk1JYThymidylate synthase/0.542
1fwmCB3Thymidylate synthase/0.539
1f4fTP3Thymidylate synthase/0.525
3bhrTHGThymidylate synthase/0.523
1tysDHFThymidylate synthase/0.518
4fogC2FThymidylate synthase ThyA/0.513
1tduCB3Thymidylate synthase/0.507
1dduCB3Thymidylate synthase/0.484
1f4gTP4Thymidylate synthase/0.472
1tlcF89Thymidylate synthase/0.463
4ez8DHFThymidylate synthase2.1.1.450.462
1an5CB3Thymidylate synthase/0.460
2vf0F89Thymidylate synthase/0.448
4o7uTHFThymidylate synthase/0.442