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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4k42ADPActin, alpha skeletal muscle

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4k42ADPActin, alpha skeletal muscle/1.000
3m6gATPActin, alpha skeletal muscle/0.617
4pkgATPActin, alpha skeletal muscle/0.605
1lotATPActin, alpha skeletal muscle/0.602
1t44ATPActin, alpha skeletal muscle/0.595
3tu5ATPActin, alpha skeletal muscle/0.595
2q36ATPActin, alpha skeletal muscle/0.594
2v51ATPActin, alpha skeletal muscle/0.589
1c0fATPMajor actin/0.588
3mn6ATPActin-5C/0.587
1h1vATPActin, alpha skeletal muscle/0.586
4pkhADPActin, alpha skeletal muscle/0.586
5ce3ATPActin/0.585
4pl8ATPActin, alpha skeletal muscle/0.578
1s22ATPActin, alpha skeletal muscle/0.575
1nmdATPMajor actin/0.572
1qz5ATPActin, alpha skeletal muscle/0.564
3u9dATPActin, alpha skeletal muscle/0.563
3a5mATPMajor actin/0.561
1mduATPActin, alpha skeletal muscle/0.560
1rgiATPActin, alpha skeletal muscle/0.560
4jhdANPActin-5C/0.559
1eqyATPActin, alpha skeletal muscle/0.550
3el2ATPActin-5C/0.550
4ci6ATPActin/0.547
3m1fATPActin, alpha skeletal muscle/0.546
4m63ATPActin-5C/0.546
3ffkATPActin, alpha skeletal muscle/0.545
4cbxATPActin-2/0.542
1kxpATPActin, alpha skeletal muscle/0.541
3mn9ATPActin-5C/0.539
4k41ATPActin, alpha skeletal muscle/0.536
1nm1ATPMajor actin/0.532
3w3dATPActin, gamma-enteric smooth muscle/0.530
1yxqATPActin, alpha skeletal muscle/0.529
3u4lATPActin, cytoplasmic 1/0.527
1ijjATPActin, alpha skeletal muscle/0.526
4pkiATPActin, alpha skeletal muscle/0.525
4k43ADPActin, alpha skeletal muscle/0.523
2q97ATPActin, alpha skeletal muscle/0.518
3dawATPActin, alpha skeletal muscle/0.513
2p9kATPActin-related protein 2/0.505
3eksATPActin-5C/0.503
4rwtANPActin-5C/0.498
2a41ATPActin, alpha skeletal muscle/0.484
3mn7ATPActin-5C/0.484
1dejATPMajor actin/0.480
3a5oATPMajor actin/0.477
2oanATPActin, cytoplasmic 1/0.475
3ekuATPActin-5C/0.465
1nlvATPMajor actin/0.440