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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4j83SAMHistone-lysine N-methyltransferase SETD72.1.1.43

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4j83SAMHistone-lysine N-methyltransferase SETD72.1.1.431.000
3cbpSFGHistone-lysine N-methyltransferase SETD72.1.1.430.612
5jj0SAMHistone-lysine N-methyltransferase EHMT2/0.522
3pdnSFGHistone-lysine N-methyltransferase SMYD32.1.1.430.507
5jhnSAMHistone-lysine N-methyltransferase EHMT2/0.502
3hnaSAHHistone-lysine N-methyltransferase EHMT1/0.501
5jinSAMHistone-lysine N-methyltransferase EHMT2/0.499
1mlvSAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.494
2o8jSAHHistone-lysine N-methyltransferase EHMT2/0.493
3mo0SAHHistone-lysine N-methyltransferase EHMT1/0.493
3n71SFGHistone-lysine N-methyltransferase Smyd1/0.485
2igqSAHHistone-lysine N-methyltransferase EHMT1/0.483
2h21SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.470
5hq8SAHHistone-lysine N-methyltransferase SMYD32.1.1.430.470
4rvgTYDD-mycarose 3-C-methyltransferase/0.465
3ru0SFGHistone-lysine N-methyltransferase SMYD32.1.1.430.464
3veu0GOBeta-secretase 13.4.23.460.459
2g247IGRenin3.4.23.150.457
3d91REMRenin3.4.23.150.457
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.457
3ribSAHN-lysine methyltransferase SMYD2/0.456
2iko7IGRenin3.4.23.150.455
4dpf0LGBeta-secretase 13.4.23.460.455
3hl0NADMaleylacetate reductase/0.454
4j4nD44Peptidylprolyl isomerase/0.454
4o30SAHProbable Histone-lysine N-methyltransferase ATXR52.1.1.430.454
1p0ySAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.453
3kmtSAHHistone H3K27 methylase/0.453
2g226IGRenin3.4.23.150.452
5czySAMEukaryotic huntingtin interacting protein B/0.452
3fpdSAHHistone-lysine N-methyltransferase EHMT1/0.451
2hizLIJBeta-secretase 13.4.23.460.448
3g0bT22Dipeptidyl peptidase 4/0.448
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.446
3m53SAHHistone-lysine N-methyltransferase SETD72.1.1.430.444
4driRAPSerine/threonine-protein kinase mTOR2.7.11.10.444
4driRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.444
2iqgF2IBeta-secretase 13.4.23.460.443
3ooiSAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific2.1.1.430.443
3tg4SAMN-lysine methyltransferase SMYD2/0.443
2bf4FADNADPH--cytochrome P450 reductase/0.442
2p83MR0Beta-secretase 13.4.23.460.442
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.440
4k9h1QUBeta-secretase 13.4.23.460.440