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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ix5ANPUncharacterized protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ix5ANPUncharacterized protein/1.000
4ix6ADPUncharacterized protein/0.645
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.486
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.458
1jstATPCyclin-dependent kinase 22.7.11.220.457
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.455
4ix4ADPUncharacterized protein/0.455
4ii5ADPCyclin-dependent kinase 22.7.11.220.454
4eooATPCyclin-dependent kinase 22.7.11.220.453
2cjmATPCyclin-dependent kinase 22.7.11.220.448
4qnyANPMitogen activated protein kinase, putative/0.447
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.445
5dnrATPAurora kinase A2.7.11.10.441
3nszANPCasein kinase II subunit alpha2.7.11.10.440
4jr7GNPCasein kinase II subunit alpha2.7.11.10.440