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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ii5ADPCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ii5ADPCyclin-dependent kinase 22.7.11.221.000
4eooATPCyclin-dependent kinase 22.7.11.220.581
4i3zADPCyclin-dependent kinase 22.7.11.220.577
1qmzATPCyclin-dependent kinase 22.7.11.220.554
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.503
2cjmATPCyclin-dependent kinase 22.7.11.220.500
4qnyANPMitogen activated protein kinase, putative/0.496
5eg3ACPFibroblast growth factor receptor 2/0.473
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.467
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.467
1jstATPCyclin-dependent kinase 22.7.11.220.462
4xlvACPInsulin receptor2.7.10.10.461
2cciATPCyclin-dependent kinase 22.7.11.220.459
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.458
4btjATPTau-tubulin kinase 12.7.11.10.455
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.452
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.451
4e4n0NLTyrosine-protein kinase JAK1/0.451
4fv6E57Mitogen-activated protein kinase 12.7.11.240.450
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.449
4s33ANPMitogen-activated protein kinase 12.7.11.240.443
5dnrATPAurora kinase A2.7.11.10.443
1jkkANPDeath-associated protein kinase 12.7.11.10.441
3i60E86Mitogen-activated protein kinase 12.7.11.240.440