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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ifvT27Gag-Pol polyprotein2.7.7.49

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ifvT27Gag-Pol polyprotein2.7.7.491.000
4id5T27Gag-Pol polyprotein2.7.7.490.772
3qlhT27Gag-Pol polyprotein2.7.7.490.752
4g1qT27Gag-Pol polyprotein2.7.7.490.741
4i2pG73Gag-Pol polyprotein2.7.7.490.703
2zd1T27Gag-Pol polyprotein2.7.7.490.656
2ze2T27Gag-Pol polyprotein2.7.7.490.624
3bgrT27Gag-Pol polyprotein2.7.7.490.595
4kfbT27Gag-Pol polyprotein2.7.7.490.583
4i2q1BTGag-Pol polyprotein2.7.7.490.576
3is9AC7Gag-Pol polyprotein2.7.7.490.563
1c1bGCAGag-Pol polyprotein2.7.7.490.556
1tl3H20Gag-Pol polyprotein2.7.7.490.547
3meeT27Gag-Pol polyprotein2.7.7.490.521
1tl1H18Gag-Pol polyprotein2.7.7.490.519
1rt4UC1Gag-Pol polyprotein2.7.7.490.516
3irxUDRGag-Pol polyprotein2.7.7.490.515
4ko0JLJGag-Pol polyprotein2.7.7.490.511
3mec65BGag-Pol polyprotein2.7.7.490.508
2hnzPC0Gag-Pol polyprotein2.7.7.490.499
4ig3T27Gag-Pol polyprotein2.7.7.490.499
4kko1REGag-Pol polyprotein2.7.7.490.496
2vg7NNIGag-Pol polyprotein2.7.7.490.489
1s6qTPBGag-Pol polyprotein2.7.7.490.483
3med65BGag-Pol polyprotein2.7.7.490.480
4rw6494Gag-Pol polyprotein2.7.7.490.478
1revTB9Gag-Pol polyprotein2.7.7.490.476
3m8p65BGag-Pol polyprotein2.7.7.490.476
3dmjGWEPol protein/0.473
1tkzH16Gag-Pol polyprotein2.7.7.490.472
1tktH12Gag-Pol polyprotein2.7.7.490.471
1hnvTBOGag-Pol polyprotein2.7.7.490.469
1rt7UC4Gag-Pol polyprotein2.7.7.490.468
3dl9V2HVitamin D 25-hydroxylase/0.467
3megT27Gag-Pol polyprotein2.7.7.490.464
3sgtP09Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)/0.463
1rt5UC2Gag-Pol polyprotein2.7.7.490.461
1vruAAPGag-Pol polyprotein2.7.7.490.461
2ban357Gag-Pol polyprotein2.7.7.490.460
4j6cSTRCytochrome P450 monooxygenase/0.460
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.460
1ikyMSDGag-Pol polyprotein2.7.7.490.459
3lalKRVGag-Pol polyprotein2.7.7.490.458
1ikwEFZGag-Pol polyprotein2.7.7.490.457
2vg5NNCGag-Pol polyprotein2.7.7.490.457
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.456
1s9eADBGag-Pol polyprotein2.7.7.490.455
2wonZZEGag-Pol polyprotein2.7.7.490.455
1s1wUC1Gag-Pol polyprotein2.7.7.490.454
1tvrTB9Gag-Pol polyprotein2.7.7.490.454
1eetBFUGag-Pol polyprotein2.7.7.490.453
3sh0SAXDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.453
3l8p0CEAngiopoietin-1 receptor2.7.10.10.451
1jlcFTCGag-Pol polyprotein2.7.7.490.450
4mfb29TGag-Pol polyprotein2.7.7.490.450
2xytTC9Soluble acetylcholine receptor/0.449
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.448
2q9fC3SCholesterol 24-hydroxylase/0.447
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.447
4rw4494Gag-Pol polyprotein2.7.7.490.447
1tkxGWBGag-Pol polyprotein2.7.7.490.446
2rf2MRXGag-Pol polyprotein2.7.7.490.446
2opqHBQGag-Pol polyprotein2.7.7.490.445
3c6uM22Gag-Pol polyprotein2.7.7.490.445
3q44D50M1 family aminopeptidase3.4.110.445
4h4o506Gag-Pol polyprotein2.7.7.490.444
2yneNHWGlycylpeptide N-tetradecanoyltransferase/0.443
3uzcT4EAdenosine receptor A2a/0.443
1zhzERGOxysterol-binding protein homolog 4/0.442
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.441
1ikxPNUGag-Pol polyprotein2.7.7.490.440
1zhwHC2Oxysterol-binding protein homolog 4/0.440
3ar7TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.440
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.440
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.440
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.440
5a27MYAGlycylpeptide N-tetradecanoyltransferase/0.440