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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4i521HA1,4-dihydroxy-2-naphthoyl-CoA synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4i521HA1,4-dihydroxy-2-naphthoyl-CoA synthase/1.000
4i4z2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.633
3t88S0N1,4-dihydroxy-2-naphthoyl-CoA synthase/0.591
4i421HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.558
4qij1HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.543
1q51CAA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.527
4qii2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.523
2uzfCAA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.503
1bim0QBRenin3.4.23.150.465
3sglFADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC/0.465
3gw9VNILanosterol 14-alpha-demethylase/0.459
3lpkZ76Beta-secretase 13.4.23.460.456
3vyeVYERenin3.4.23.150.452
2iqgF2IBeta-secretase 13.4.23.460.451
2g247IGRenin3.4.23.150.450
3vswR31Renin3.4.23.150.448
2p83MR0Beta-secretase 13.4.23.460.447
3cic316Beta-secretase 13.4.23.460.444
3r7kFDAProbable acyl CoA dehydrogenase/0.444
2g1s4IGRenin3.4.23.150.443
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
1rneC60Renin3.4.23.150.442
3ixj586Beta-secretase 13.4.23.460.442
3vsxR32Renin3.4.23.150.442
2ebaFADPutative glutaryl-CoA dehydrogenase/0.440
3cid318Beta-secretase 13.4.23.460.440
3lpiZ74Beta-secretase 13.4.23.460.440