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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4hzoCOAConserved hypthetical protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4hzoCOAConserved hypthetical protein/1.000
4hzpCOAConserved hypthetical protein/0.702
2du8FADD-amino-acid oxidase1.4.3.30.500
3if9FADGlycine oxidase1.4.3.190.494
1ng3FADGlycine oxidase1.4.3.190.483
2e48FADD-amino-acid oxidase1.4.3.30.481
5idwNAPShort-chain dehydrogenase/reductase SDR/0.474
3cukFADD-amino-acid oxidase1.4.3.30.472
1kifFADD-amino-acid oxidase1.4.3.30.467
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.465
3znpFADD-amino-acid oxidase1.4.3.30.463
4yshFADGlycine oxidase/0.461
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.459
4dk70KSOxysterols receptor LXR-beta/0.459
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.456
1ng4FADGlycine oxidase1.4.3.190.455
1snyNAPLD36273p/0.455
2wdzNADGalactitol dehydrogenase/0.455
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.453
3vtdTKDVitamin D3 receptor/0.452
1ryiFADGlycine oxidase1.4.3.190.451
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
4c4oNADSADH/0.449
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.447
1w4zNAPPutative ketoacyl reductase1.3.10.447
2xveFADPutative flavin-containing monooxygenase/0.447
3siiA1RUncharacterized protein/0.447
4lcjNADC-terminal-binding protein 2/0.447
2vnaNAPProstaglandin reductase 21.3.1.480.446
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
3tqhNDPQuinone oxidoreductase/0.445
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
2p5nNDPAldo-keto reductase family 1 member C211.1.10.444
2xlrFADPutative flavin-containing monooxygenase/0.444
4gevCB3Thymidylate synthase/0.444
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1p0fNAPNADP-dependent alcohol dehydrogenase1.1.1.20.443
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1kqnNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.442
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.442
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.441
3da1FADGlycerol-3-phosphate dehydrogenase/0.441
4xguADPPutative pachytene checkpoint protein 2/0.441
1db1VDXVitamin D3 receptor/0.440
1f4fTP3Thymidylate synthase/0.440
2c3qGTXGlutathione S-transferase theta-12.5.1.180.440
3nwzCOABH2602 protein/0.440