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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4h570PJThermolysin3.4.24.27

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4h570PJThermolysin3.4.24.271.000
6tmn0PIThermolysin3.4.24.270.650
3t87UBZThermolysin3.4.24.270.638
3t74UBYThermolysin3.4.24.270.630
3t8cUBWThermolysin3.4.24.270.624
4tmn0PKThermolysin3.4.24.270.619
4d9wX32Thermolysin3.4.24.270.604
3t8dUBVThermolysin3.4.24.270.600
3t8hUBSThermolysin3.4.24.270.598
3forZNPThermolysin3.4.24.270.590
3fgdBYAThermolysin3.4.24.270.568
4tlnLNOThermolysin3.4.24.270.568
2tmn0FAThermolysin3.4.24.270.565
3f28S7BThermolysin3.4.24.270.544
4b52RDFBacillolysin/0.516
1qf2TI3Thermolysin3.4.24.270.499
3f2pS3BThermolysin3.4.24.270.481
4araC56Acetylcholinesterase3.1.1.70.469
1q84TZ4Acetylcholinesterase3.1.1.70.463
3q43D66M1 family aminopeptidase3.4.110.453
5f8eSAHPossible transcriptional regulatory protein/0.447
4zr5RDFNeprilysin/0.446
2oc2RX3Angiotensin-converting enzyme3.2.10.445
1w6hTITPlasmepsin-23.4.23.390.444
4dfg0JVGag-Pol polyprotein3.4.23.160.444
5irnADPNucleotide binding oligomerization domain containing 2/0.443
2pj4414Carboxypeptidase B/0.442
1lf3EH5Plasmepsin-23.4.23.390.440