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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ggzBTNBll1558 protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ggzBTNBll1558 protein/1.000
1nc9IMIStreptavidin/0.576
3wypBSOStreptavidin/0.543
1swnBTNStreptavidin/0.526
1ndjBTNStreptavidin/0.523
1n43BTNStreptavidin/0.520
1swdBTNStreptavidin/0.518
1swpBTQStreptavidin/0.514
4z28BTNHoefavidin/0.513
1sweBTNStreptavidin/0.504
1n9mBTNStreptavidin/0.502
3t2wBTNAvidin/streptavidin/0.501
1sreHABStreptavidin/0.498
1mepBTNStreptavidin/0.497
1swpBTNStreptavidin/0.496
2izhBTNStreptavidin/0.492
2aviBTNAvidin/0.489
1swtBTNStreptavidin/0.488
3ew2BTNHypothetical conserved protein/0.486
1rxhBNIStreptavidin/0.484
2fhnBNIAvidin-related protein 4/5/0.481
4stdBFSScytalone dehydratase4.2.1.940.480
1stpBTNStreptavidin/0.479
1srfMTBStreptavidin/0.478
4bx7B4FStreptavidin/0.476
2rtnIMIStreptavidin/0.475
1mk5BTNStreptavidin/0.474
3ry2BTNStreptavidin/0.474
2izfBTNStreptavidin/0.472
2ckmAA7Acetylcholinesterase3.1.1.70.469
4yvbBTNStreptavidin/0.469
3wyqBTNStreptavidin/0.468
1ut6A8NAcetylcholinesterase3.1.1.70.466
4gdaBTNStreptavidin/0.464
1lcwSHMStreptavidin/0.463
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
1odcA8BAcetylcholinesterase3.1.1.70.461
2rtfBTNStreptavidin/0.461
2zscBTNTamavidin2/0.461
2rtqIMIStreptavidin/0.460
3akn11DFatty acid-binding protein, intestinal/0.460
4ead0NPThymidine phosphorylase2.4.2.40.460
1eveE20Acetylcholinesterase3.1.1.70.459
1ygjRMCPyridoxal kinase2.7.1.350.459
3gdpFAD(R)-mandelonitrile lyase 24.1.2.100.459
3vgwNVZAvidin/0.458
2xufTZ4Acetylcholinesterase3.1.1.70.457
4gd9BTNStreptavidin/0.457
1srhMOBStreptavidin/0.456
2rtrIMIStreptavidin/0.456
2xukTZ5Acetylcholinesterase3.1.1.70.456
3pblETQD(3) dopamine receptor/0.456
2izgBTNStreptavidin/0.455
2izlIMIStreptavidin/0.455
3arvSAUChitinase A/0.455
1zgbA1EAcetylcholinesterase3.1.1.70.454
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.454
2w6cBM4Acetylcholinesterase3.1.1.70.454
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.454
1zgcA2EAcetylcholinesterase3.1.1.70.452
2xq0BESLeukotriene A-4 hydrolase homolog3.3.2.60.452
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.452
1sriDMBStreptavidin/0.451
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.451
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.451
2xuqTZ4Acetylcholinesterase3.1.1.70.451
4b63NAPL-ornithine N(5)-monooxygenase/0.451
1oc1ASVIsopenicillin N synthase1.21.3.10.450
4ey6GNTAcetylcholinesterase3.1.1.70.450
1qtiGNTAcetylcholinesterase3.1.1.70.449
1u65CP0Acetylcholinesterase3.1.1.70.449
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.449
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.449
4dneDTBStreptavidin/0.449
4bfwZVWPantothenate kinase2.7.1.330.448
5eghPCEctonucleotide pyrophosphatase/phosphodiesterase family member 6/0.448
3g1lRF2HTH-type transcriptional regulator EthR/0.447
4b65NDPL-ornithine N(5)-monooxygenase/0.447
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.447
1w6rGNTAcetylcholinesterase3.1.1.70.445
2rqfJH3Hemolymph juvenile hormone binding protein/0.445
2rteBTNStreptavidin/0.445
2rtoIMIStreptavidin/0.445
4bj8BTNAvidin/0.445
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.445
4gz612VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.445
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3tfyCOAN-alpha-acetyltransferase 502.3.10.443
3up0D7SaceDAF-12/0.443
4l0t1V0Tankyrase-22.4.2.300.443
4zj8SUVOrexin receptor type 1/0.443
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.442
1ta6177Prothrombin3.4.21.50.442
2xuhTZ4Acetylcholinesterase3.1.1.70.442
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4bftZVTPantothenate kinase2.7.1.330.442
4l341VGTankyrase-22.4.2.300.442
4psbGA3Cytokinin-specific binding protein/0.442
2vd0D27Hematopoietic prostaglandin D synthase/0.441
2xvfFADPutative flavin-containing monooxygenase/0.441
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1hb1OCVIsopenicillin N synthase1.21.3.10.440
1q3aNGHStromelysin-23.4.24.220.440
2iko7IGRenin3.4.23.150.440
2rtdBTNStreptavidin/0.440
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3oqkS52Renin3.4.23.150.440
3vhhVHHAvidin/0.440