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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fweFADLysine-specific histone demethylase 1B1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fweFADLysine-specific histone demethylase 1B11.000
4gutFADLysine-specific histone demethylase 1B10.627
4guuFA9Lysine-specific histone demethylase 1B10.570
3bi5FADPolyamine oxidase FMS1/0.539
4fwjFADLysine-specific histone demethylase 1B10.538
2dw4FADLysine-specific histone demethylase 1A10.524
4xbfFADLysine-specific histone demethylase 1A10.519
1xpqFADPolyamine oxidase FMS1/0.515
3cndFADPolyamine oxidase FMS1/0.511
4echFADPolyamine oxidase FMS1/0.508
3cn8FADPolyamine oxidase FMS1/0.502
3bi2FADPolyamine oxidase FMS1/0.498
4gdpFADPolyamine oxidase FMS1/0.496
2hkoFADLysine-specific histone demethylase 1A10.492
2iw5FADLysine-specific histone demethylase 1A10.491
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.491
2yg4FADPutrescine oxidase/0.489
4hsuFADLysine-specific histone demethylase 1B10.485
2uxxFAJLysine-specific histone demethylase 1A10.484
2yg5FADPutrescine oxidase/0.481
1z6lFADPolyamine oxidase FMS1/0.478
3slkNDPPolyketide synthase extender module 2/0.464
5l3dFADLysine-specific histone demethylase 1A10.464
3cntFADPolyamine oxidase FMS1/0.458
3nx4NAPPutative oxidoreductase/0.451
3t2zFADSulfide-quinone reductase/0.451
5ez7FADProbable FAD-dependent oxidoreductase PA4991/0.451
3zeiAWHO-acetylserine sulfhydrylase/0.450
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.448
5dp2NAPCurF/0.448
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3f1kNAPUncharacterized oxidoreductase YciK10.447
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
2yg3FADPutrescine oxidase/0.444
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.442
4da7AC2Purine nucleoside phosphorylase DeoD-type2.4.2.10.440