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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fue7UPUrokinase-type plasminogen activator3.4.21.73

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fue7UPUrokinase-type plasminogen activator3.4.21.731.000
2vivVG2Urokinase-type plasminogen activator3.4.21.730.564
4fuiUI3Urokinase-type plasminogen activator3.4.21.730.499
1xe55FEPlasmepsin-23.4.23.390.493
1owe675Urokinase-type plasminogen activator3.4.21.730.490
1o5gCR9Prothrombin3.4.21.50.477
1o2g696Prothrombin3.4.21.50.470
1gj5130Prothrombin3.4.21.50.469
1ejnAGBUrokinase-type plasminogen activator3.4.21.730.466
1gj4132Prothrombin3.4.21.50.460
4bti7R9Coagulation factor X3.4.21.60.457
1vja7INUrokinase-type plasminogen activator3.4.21.730.456
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.452
4hfp15UProthrombin3.4.21.50.452
1tehNADAlcohol dehydrogenase class-31.1.1.10.448
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.446
1xe65FPPlasmepsin-23.4.23.390.445
2ob0ACON-alpha-acetyltransferase 50/0.442
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.442
3sufSUEPolyprotein/0.441
4i0h1BLBeta-secretase 13.4.23.460.441
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.440
2x95X95Angiotensin-converting enzyme3.4.15.10.440
5dp2NAPCurF/0.440