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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4enhFVXCholesterol 24-hydroxylase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4enhFVXCholesterol 24-hydroxylase/1.000
3mdmFJZCholesterol 24-hydroxylase/0.608
3mdvCL6Cholesterol 24-hydroxylase/0.597
2q9fC3SCholesterol 24-hydroxylase/0.523
4g3jVNTLanosterol 14-alpha-demethylase/0.491
3p3zP3ZPutative cytochrome P450/0.474
1eupASD6-deoxyerythronolide B hydroxylase/0.469
1jioDEB6-deoxyerythronolide B hydroxylase/0.455
4g7gVFVLanosterol 14-alpha-demethylase/0.453
4tuvCPZCytochrome P450 1191.140.451
4uymVOR14-alpha sterol demethylase Cyp51B/0.451
1jipKTN6-deoxyerythronolide B hydroxylase/0.446
1phgMYTCamphor 5-monooxygenase1.14.15.10.442
1q5dEPBEpothilone C/D epoxidase1.140.441