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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4em3FADCoenzyme A disulfide reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4em3FADCoenzyme A disulfide reductase/1.000
4eqwFADCoenzyme A disulfide reductase/0.700
4em4FADCoenzyme A disulfide reductase/0.580
4eqxFADCoenzyme A disulfide reductase/0.538
4eqrFADCoenzyme A disulfide reductase/0.529
1tytFADTrypanothione reductase1.8.1.120.498
2tprFADTrypanothione reductase1.8.1.120.472
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.90.460
3ntaFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.459
3ntdFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.459
2hqmFADGlutathione reductase1.8.1.70.457
4b1bFADThioredoxin reductase1.8.1.90.453
2x8hFADThioredoxin glutathione reductase/0.446
1qiqACCIsopenicillin N synthase1.21.3.10.443
1fecFADTrypanothione reductase1.8.1.120.441