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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4elf35IDihydrofolate reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4elf35IDihydrofolate reductase/1.000
4ele31IDihydrofolate reductase/0.727
3fl8RARDihydrofolate reductase/0.677
4elh53IDihydrofolate reductase/0.587
4elg52JDihydrofolate reductase/0.564
4elb34SDihydrofolate reductase/0.563
4elb34RDihydrofolate reductase/0.547
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.529
3fl9TOPDihydrofolate reductase/0.523
2qk8MTXDihydrofolate reductase/0.515
1diuBDMDihydrofolate reductase1.5.1.30.493
1jolFFODihydrofolate reductase1.5.1.30.493
1draMTXDihydrofolate reductase1.5.1.30.488
1ddrMTXDihydrofolate reductase1.5.1.30.485
4dfrMTXDihydrofolate reductase1.5.1.30.480
2drcMTXDihydrofolate reductase1.5.1.30.475
1drbMTXDihydrofolate reductase1.5.1.30.472
3och2MXDihydrofolate reductase1.5.1.30.472
1disBDMDihydrofolate reductase1.5.1.30.467
1tdrMTXDihydrofolate reductase1.5.1.30.467
1rf7DHFDihydrofolate reductase1.5.1.30.466
1dyjDDFDihydrofolate reductase1.5.1.30.463
1rc4DDFDihydrofolate reductase1.5.1.30.461
1dhjMTXDihydrofolate reductase1.5.1.30.458
1ddsMTXDihydrofolate reductase1.5.1.30.456
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
3syiFADSulfide-quinone reductase/0.454
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.453
4xe606UDihydrofolate reductase1.5.1.30.452
3kpkFADSulfide-quinone reductase/0.450
3t2zFADSulfide-quinone reductase/0.449
3drcMTXDihydrofolate reductase1.5.1.30.448
3m08RARDihydrofolate reductase1.5.1.30.448
4iarERM5-hydroxytryptamine receptor 1B/0.448
1iyzNDPProbable quinone oxidoreductase/0.447
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.445
3t8xT8XT-cell surface glycoprotein CD1b/0.444
2om9AJAPeroxisome proliferator-activated receptor gamma/0.443
3sz0FADSulfide-quinone reductase/0.442
1re7FOLDihydrofolate reductase1.5.1.30.441
4cd2FOLDihydrofolate reductase1.5.1.30.441
1tduCB3Thymidylate synthase/0.440
4ryvZEAProtein LlR18A/0.440
5hi6MTXDihydrofolate reductase/0.440