Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4einNOHThymidylate synthase2.1.1.45

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4einNOHThymidylate synthase2.1.1.451.000
4e5oUMPThymidylate synthase2.1.1.450.554
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.549
4eb4UMPThymidylate synthase2.1.1.450.544
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.536
1njcDCMThymidylate synthase/0.526
1njdUMPThymidylate synthase/0.526
2g8aUMPThymidylate synthase/0.526
1tsyUMPThymidylate synthase/0.522
1jmgUMPThymidylate synthase/0.519
1jmiUMPThymidylate synthase/0.516
1bp6UMPThymidylate synthase/0.515
2g89UMPThymidylate synthase/0.515
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.514
4dq1UMPThymidylate synthase/0.510
2tdmUMPThymidylate synthase/0.508
1njaDCMThymidylate synthase/0.506
1tsxUMPThymidylate synthase/0.506
2g86UMPThymidylate synthase/0.499
1bidUMPThymidylate synthase/0.498
1vzbUMPThymidylate synthase/0.498
1njbUMPThymidylate synthase/0.494
1jmfUMPThymidylate synthase/0.493
1ci7UMPThymidylate synthase2.1.1.450.492
5by6UMPThymidylate synthase/0.490
2g8dUMPThymidylate synthase/0.489
1tsvUMPThymidylate synthase/0.486
1njeDCMThymidylate synthase/0.481
1aobDDUThymidylate synthase/0.480
1vzaUMPThymidylate synthase/0.479
1bpjUMPThymidylate synthase/0.478
1bp0UMPThymidylate synthase/0.477
3bgxTMPThymidylate synthase/0.477
3qj7UMPThymidylate synthase ThyA/0.476
1jmhUMPThymidylate synthase/0.463
4foxUMPThymidylate synthase ThyA/0.463
1lcbTMPThymidylate synthase/0.462
4xsdUMPThymidylate synthase2.1.1.450.461
4irrUMPThymidylate synthase/0.455
1dduDDUThymidylate synthase/0.452
1bduDURThymidylate synthase/0.451
4h0uUMPThymidylate synthase/0.450
4iskUMPThymidylate synthase/0.448
2tsrUMPThymidylate synthase2.1.1.450.442