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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ea0651Dehydrosqualene synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ea0651Dehydrosqualene synthase/1.000
2zcqB65Dehydrosqualene synthase/0.596
3tfn2CJDehydrosqualene synthase/0.585
4ea13RXDehydrosqualene synthase/0.570
3acy702Dehydrosqualene synthase/0.559
3tfp03LDehydrosqualene synthase/0.537
4f6vZYMDehydrosqualene synthase/0.533
4ea2RWZDehydrosqualene synthase/0.512
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.455
3acw651Dehydrosqualene synthase/0.452
3q30D61Squalene synthase2.5.1.210.440