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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4e5oUMPThymidylate synthase2.1.1.45

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4e5oUMPThymidylate synthase2.1.1.451.000
4einNOHThymidylate synthase2.1.1.450.660
4eb4UMPThymidylate synthase2.1.1.450.627
4dq1UMPThymidylate synthase/0.595
2g89UMPThymidylate synthase/0.588
4irrUMPThymidylate synthase/0.585
1njdUMPThymidylate synthase/0.583
5by6UMPThymidylate synthase/0.582
1njcDCMThymidylate synthase/0.581
2g8aUMPThymidylate synthase/0.567
3qj7UMPThymidylate synthase ThyA/0.564
1aobDDUThymidylate synthase/0.563
2g8dUMPThymidylate synthase/0.556
1bidUMPThymidylate synthase/0.555
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.555
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.554
4psgNOHThymidylate synthase/0.552
1njbUMPThymidylate synthase/0.550
1jmiUMPThymidylate synthase/0.549
2g86UMPThymidylate synthase/0.549
1bp6UMPThymidylate synthase/0.548
4h0uUMPThymidylate synthase/0.548
1tsvUMPThymidylate synthase/0.547
1jmgUMPThymidylate synthase/0.545
1tsyUMPThymidylate synthase/0.543
1tsxUMPThymidylate synthase/0.540
1njeDCMThymidylate synthase/0.539
2tdmUMPThymidylate synthase/0.536
4xsdUMPThymidylate synthase2.1.1.450.534
3hb8UMPThymidylate synthase2.1.1.450.530
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.528
1ci7UMPThymidylate synthase2.1.1.450.526
1jmfUMPThymidylate synthase/0.525
1bp0UMPThymidylate synthase/0.522
1bduDURThymidylate synthase/0.521
1jmhUMPThymidylate synthase/0.517
1bpjUMPThymidylate synthase/0.511
1dduDDUThymidylate synthase/0.511
3bhrTHGThymidylate synthase/0.510
1njaDCMThymidylate synthase/0.503
2vetUMPThymidylate synthase/0.503
1lcbTMPThymidylate synthase/0.496
1dduCB3Thymidylate synthase/0.494
4isk1JYThymidylate synthase/0.493
2tsrUMPThymidylate synthase2.1.1.450.484
1vzbUMPThymidylate synthase/0.479
1vzaUMPThymidylate synthase/0.478
1an5CB3Thymidylate synthase/0.477
4ez8DHFThymidylate synthase2.1.1.450.476
1lcbDHFThymidylate synthase/0.474
4iskUMPThymidylate synthase/0.474
3bgxTMPThymidylate synthase/0.472
4lrrCF9Thymidylate synthase/0.471
1tdcUMPThymidylate synthase/0.465
1j3jUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.461
4iqqUMPThymidylate synthase/0.458
4foxUMPThymidylate synthase ThyA/0.454
1thyUMPThymidylate synthase/0.440