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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dwb0M7Farnesyl pyrophosphate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dwb0M7Farnesyl pyrophosphate synthase/1.000
3dyh721Farnesyl pyrophosphate synthase/0.595
3ldwZOLFarnesyl pyrophosphate synthase, putative/0.587
2f94BFQFarnesyl pyrophosphate synthase2.5.1.100.576
4kqsRISFarnesyl pyrophosphate synthase2.5.1.100.568
4dxj0M9Farnesyl pyrophosphate synthase/0.567
1zw5ZOLFarnesyl pyrophosphate synthase2.5.1.100.566
3ez3ZOLFarnesyl pyrophosphate synthase, putative/0.564
3egt722Farnesyl pyrophosphate synthase/0.559
4kqsIPEFarnesyl pyrophosphate synthase2.5.1.100.555
3rywK9HFarnesyl pyrophosphate synthase, putative/0.548
4q23RISFarnesyl pyrophosphate synthase2.5.1.100.548
4lfgIPEPutative geranyltranstransferase/0.545
3ldwIPEFarnesyl pyrophosphate synthase, putative/0.544
3rbmB73Farnesyl pyrophosphate synthase, putative/0.543
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.533
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.531
2i191BYFarnesyl pyrophosphate synthase/0.528
3ryeUNRFarnesyl pyrophosphate synthase2.5.1.100.527
3oabDSTGeranyl diphosphate synthase large subunit/0.524
3krfDSTGeranyl diphosphate synthase large subunit/0.517
1yv5RISFarnesyl pyrophosphate synthase2.5.1.100.514
1yq7RISFarnesyl pyrophosphate synthase2.5.1.100.513
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.510
3ez3IPEFarnesyl pyrophosphate synthase, putative/0.508
4nkeRISFarnesyl pyrophosphate synthase2.5.1.100.507
4nkeIPEFarnesyl pyrophosphate synthase2.5.1.100.507
1rqjRISFarnesyl diphosphate synthase2.5.1.100.505
3krfIPEGeranyl diphosphate synthase large subunit/0.503
2opnSUFFarnesyl pyrophosphate synthase2.5.1.100.497
5ero210Fusicoccadiene synthase2.5.1.290.490
1rqjIPEFarnesyl diphosphate synthase2.5.1.100.485
4k10NI9Farnesyl pyrophosphate synthase/0.477
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.100.463
3iczPB6Farnesyl pyrophosphate synthase/0.459
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.455
2zevIPEGeranylgeranyl pyrophosphate synthase/0.451
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.451
2e8tIPEGeranylgeranyl pyrophosphate synthase/0.447
2e91ZOLGeranylgeranyl pyrophosphate synthase/0.447
2oapANPType II secretion system protein (GspE-2)/0.447
1wkhPPE[LysW]-aminoadipate semialdehyde transaminase/0.445
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.444
3q9lATPSeptum site-determining protein MinD/0.443
4yb7ATPATP phosphoribosyltransferase/0.442
2j4dFADCryptochrome DASH, chloroplastic/mitochondrial/0.441
3buzLARActin, alpha skeletal muscle/0.441
2e94364Geranylgeranyl pyrophosphate synthase/0.440
2z78H86Geranylgeranyl pyrophosphate synthase/0.440