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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dijBLFE3 ubiquitin-protein ligase Mdm26.3.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dijBLFE3 ubiquitin-protein ligase Mdm26.3.21.000
3vt7VDXVitamin D3 receptor/0.466
1rv1IMZE3 ubiquitin-protein ligase Mdm26.3.20.463
4erf0R3E3 ubiquitin-protein ligase Mdm26.3.20.459
1m13HYFNuclear receptor subfamily 1 group I member 2/0.457
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
3vt9YI4Vitamin D3 receptor/0.452
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
1f4fTP3Thymidylate synthase/0.449
2ca0PXICytochrome P450 monooxygenase PikC/0.447
3cv9VDXVitamin D3 dihydroxylase/0.447
1jipKTN6-deoxyerythronolide B hydroxylase/0.446
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3gw9VNILanosterol 14-alpha-demethylase/0.446
4g7gVFVLanosterol 14-alpha-demethylase/0.446
2uxoTACHTH-type transcriptional regulator TtgR/0.445
1tduCB3Thymidylate synthase/0.442
4jvr1MTE3 ubiquitin-protein ligase Mdm26.3.20.441
1zeoC01Peroxisome proliferator-activated receptor gamma/0.440