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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4deeADPAurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4deeADPAurora kinase A2.7.11.11.000
5dnrATPAurora kinase A2.7.11.10.568
5dosATPAurora kinase A2.7.11.10.554
3c4zADPRhodopsin kinase/0.494
4o0wADNAurora kinase A2.7.11.10.482
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.459
4qnyANPMitogen activated protein kinase, putative/0.459
5dn3ATPAurora kinase A2.7.11.10.456
3c4wATPRhodopsin kinase/0.454
4c3pACPAurora kinase A2.7.11.10.450
4jbpYPHAurora kinase A2.7.11.10.442
4jboWPHAurora kinase A2.7.11.10.441